Cognitive and emotional alterations in young Alzheimer's disease (3xTgAD) mice: effects of neonatal handling stimulation and sexual dimorphism

T Cañete, G Blázquez, A Tobeña… - Behavioural brain …, 2015 - Elsevier
cognitive alterations characteristic of the disease. The present study intended to examine …
3xTgAD mice of both sexes present cognitive, emotional and other behavioral alterations at …

[HTML][HTML] … , and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling

R Baeta-Corral, M De la Fuente… - Behavioural Brain …, 2023 - Elsevier
… that neonatal handling may exert a potential modification of … the first time this sex dimorphism
in the 3xTg-AD mice. Moreover, … Cognitive and emotional alterations in young Alzheimer's

Bizarre behaviors and risk assessment in 3xTg-AD mice at early stages of the disease

R Baeta-Corral, L Giménez-Llort - Behavioural brain research, 2014 - Elsevier
… as postnatal handling (PH), a tactile sensorial stimulation … -related cognitive or histological
changes However, the effects of … , rearings consistently showed sexual dimorphism while the …

Sexual dimorphism in the 3xTg-AD mouse model and its impact on pre-clinical research

JL Dennison, NR Ricciardi, I Lohse… - … Alzheimer's disease, 2021 - content.iospress.com
… experience worse pathology and faster cognitive decline. Pre-clinical … modifications such as
methylation and acetylation [31]. These … and no analysis was performed on AβPP processing

Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure

JC Carroll, ER Rosario, S Kreimer, A Villamagna… - Brain research, 2010 - Elsevier
… that neonatal demasculinization of male 3xTg-AD mice altered … approaches, mounting and
stimulus bedding preference. First… Progressive and gender-dependent cognitive impairment in …

… handling and environmental enrichment improve the behavioral responses of 17-month-old 3xTg-AD and non-transgenic mice in the Forced Swim Test in a gender …

V Torres-Lista, L Giménez-Llort - Behavioural processes, 2015 - Elsevier
… ) and emotional alterations appearing in 3xTg-AD mice at … not sensorial stimulation by early-life
postnatal handling during the … Age-dependent sexual dimorphism in cognition and stress …

Water and T-maze protocols are equally efficient methods to assess spatial memory in 3xTg Alzheimer's disease mice

KE Davis, K Burnett, J Gigg - Behavioural brain research, 2017 - Elsevier
… Here, we first confirmed that 3xTgAD mice express fear … Age-dependent sexual
dimorphism in cognition and stress … Cognitive and emotional alterations in young Alzheimer’s …

Social nesting, animal welfare, and disease monitoring

L Giménez-Llort, V Torres-Lista - Animals, 2021 - mdpi.com
… , cognitive, and behavioral effects of neonatal handling in … of male and female 3xTg-AD
mice in social nesting under … activity, but not the modification of vertical exploratory activity, …

[HTML][HTML] Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve

SL Lesuis, L Hoeijmakers, A Korosi… - Alzheimer's …, 2018 - alzres.biomedcentral.com
… spatial cognitive deficits and emotional alterations at 4 months of age in 3xTg-AD mice, an
effect … showing protective effects of environmental stimuli, such as housing mice in enriched …

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer's disease

Y Gloria, K Ceyzériat, S Tsartsalis, P Millet… - Scientific reports, 2021 - nature.com
… could have consequences in behavior and cognitive function… effects (locomotion and locomotor
response to stimulation of D 2 … that 3xTg-AD mice show dopaminergic system alterations